The cell membrane consists primarily of a thin layer of amphipathic phospholipids that spontaneously arrange so that the hydrophobic "tail" regions are isolated from the surrounding water while the hydrophilic "head" regions interact with the intracellular (cytosolic) and extracellular faces of the resulting bilayer. Considering this, why is the cell membrane hydrophilic and hydrophobic? The hydrophilic phosphate heads like water, so they touch the inside and the outside of the cell where the environments are aqueous. The fatty acid tails form a hydrophobic region in the middle, which is free of water. This cell membrane helps in structuring the cell and also controls which substances can cross it. Beside above, is the interior of a cell membrane hydrophilic? Thus, the membrane surfaces that face the interior and exterior of the cell are hydrophilic . In contrast, the interior of the cell membrane is hydrophobic and will not interact with water. Thi...